Manning Chases TD Record Against 49ers on Sunday Night Football

Denver Opened as a 7-point Home Favorite Against San Francisco.

The Week 7 NFL Sunday Night Football matchup will feature two teams coming off nearly identical wins and a future Hall of Fame quarterback trying to break Brett Favre's NFL career record for touchdown passes. The Denver Broncos (4-1) and QB Peyton Manning will host the San Francisco 49ers (4-2), opening as 7-point favorites at the Westgate Las Vegas SuperBook with the total set at 51. Those numbers have since come down slightly despite Manning likely going for three touchdowns or more to set the new league mark (click here to check latest NFL odds).

The Broncos and 49ers each won 31-17 last week on the road, and both got interception returns for touchdowns in the final minute to close out their opponents. Denver beat the New York Jets as a 10-point favorite and needed that final score to cover the spread while San Francisco defeated the St. Louis Rams as 3.5-point chalk. These teams have not met since 2010, when they squared off in London and QB Troy Smith led the Niners to a 24-16 victory as 2-point favorites. Brandon Lloyd was the leading receiver for the Broncos in that game with 169 yards and one touchdown, and he is now playing for San Francisco.

Lloyd's 80-yard touchdown catch from QB Colin Kaepernick ignited the 49ers offense at the end of the first half against the Rams, as they rallied back from an early 14-0 deficit by scoring 24 unanswered points en route to the win. San Francisco's defense did take a blow though when middle linebacker Patrick Willis hurt his toe. Willis is expected to miss the game along with offensive guard Mike Iupati, who suffered a concussion at St. Louis (click here to check updated NFL injury report).

Denver is 2-0 against the spread in its past two games after starting the season 0-3 ATS, with the total going "over" in two straight following two consecutive "unders" in the team's previous two games. The Broncos have yet to play their best game, as all of their opponents have been within a touchdown of them in the fourth quarter. Manning has thrown seven TD passes combined over the last two games and will look to dictate the tempo against the 49ers through the air without much of a running game.

San Francisco has won five of the past seven meetings with Denver both straight-up and vs. the line, but the team is just 1-4 ATS in its last five road games against AFC West opponents. The Broncos are 8-3 ATS in their past 11 home games against NFC West opponents, with the total going "over" in six straight.